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1

Congenital myasthenic syndromes: pathogenesis, diagnosis, and treatment

Engel, Andrew G, Shen, Xin-Ming, Selcen, Duygu, Sine, Steven M

Journal:

The Lancet Neurology

Year:

2015

Language:

english

File:

PDF, 4.12 MB

english, 2015

2

Potentiation of a neuronal nicotinic receptor via pseudo-agonist site

Mazzaferro, Simone, Bermudez, Isabel, Sine, Steven M.

Journal:

Cellular and Molecular Life Sciences

Year:

2019

Language:

english

File:

PDF, 2.59 MB

english, 2019

3

Congenital myasthenic syndromes: Progress over the past decade

Andrew G. Engel, Kinji Ohno, Steven M. Sine

Journal:

Year:

2003

Language:

english

File:

PDF, 371 KB

english, 2003

4

Design and construction of a multimedia technology cart

Fred T. Hofstetter, Michael Morgan, Patricia Sine, Steven Timmins, James Wilson

Journal:

Year:

1993

Language:

english

File:

PDF, 526 KB

english, 1993

5

Mutation of the acetylcholine receptor α subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity

Steven M. Sine, Kinji Ohno, Cecilia Bouzat, Anthony Auerbach, Margherita Milone, Jerry N. Pruitt, Andrew G. Engel

Journal:

Year:

1995

Language:

english

File:

PDF, 1.32 MB

english, 1995

6

Slow-channel mutation in acetylcholine receptor αM4 domain and its efficient knockdown

Xin-Ming Shen, Feza Deymeer, Steven M. Sine, Andrew G. Engel

Journal:

Annals of Neurology

Year:

2006

Language:

english

File:

PDF, 285 KB

english, 2006

7

End-plate acetylcholine receptor deficiency due to nonsense mutations in the ε subunit

Dr Andrew G. Engel, Kinji Ohno, Cecilia Bouzat, Steven M. Sine, Robert C. Griggs

Journal:

Annals of Neurology

Year:

1996

Language:

english

File:

PDF, 804 KB

english, 1996

8

The nicotinic receptor ligand binding domain

Journal:

Developmental Neurobiology

Year:

2002

Language:

english

File:

PDF, 716 KB

english, 2002

9

Surface impedance measurements of cuprate superconductors: Nd1.85.85Ce0.15CuO4−δ—A case study

Steven M. Anlage, Dong -Ho Wu, Jian Mao, Sining Mao, X. X. Xi, T. Venkatesan, J. L. Peng, R. L. Greene

Journal:

Journal of Superconductivity and Novel Magnetism

Year:

1994

Language:

english

File:

PDF, 518 KB

english, 1994

10

What Have We Learned from the Congenital Myasthenic Syndromes

Andrew G. Engel, Xin-Ming Shen, Duygu Selcen, Steven M. Sine

Journal:

Journal of Molecular Neuroscience

Year:

2010

Language:

english

File:

PDF, 772 KB

english, 2010

11

On the Origin of Ion Selectivity in the Cys-Loop Receptor Family

Steven M. Sine, Hai-Long Wang, Scott Hansen, Palmer Taylor

Journal:

Journal of Molecular Neuroscience

Year:

2010

Language:

english

File:

PDF, 541 KB

english, 2010

12

Congenital Myasthenic Syndromes: New Insights from Molecular Genetic and Patch-Clamp Studies

ANDREW G. ENGEL, KINJI OHNO, MARGHERITA MILONE, STEVEN M. SINE

Journal:

Annals of the New York Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 950 KB

english, 1998

13

10.1038/6326

Sine, Steven M., Wang, Hai-Long, Milone, Margherita, Ohno, Kinji, Shen, Xing-Ming, Tsujino, Akira, Batocchi, Anna Paola, Tonali, Pietro, Brengman, Joan, Engel, Andrew G.

Journal:

Nature Neuroscience

Year:

1999

Language:

english

File:

PDF, 891 KB

english, 1999

14

10.1038/8161

Wang, Hai-Long, Milone, Margherita, Ohno, Kinji, Shen, Xing-Ming, Tsujino, Akira, Batocchi, Anna Paola, Tonali, Pietro, Brengman, Joan, Engel, Andrew G., Sine, Steven M.

Journal:

Nature Neuroscience

Year:

1999

Language:

english

File:

PDF, 737 KB

english, 1999

15

Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel

Bouzat, Cecilia, Gumilar, Fernanda, Spitzmaul, Guillermo, Wang, Hai-Long, Rayes, Diego, Hansen, Scott B., Taylor, Palmer, Sine, Steven M.

Journal:

Year:

2004

Language:

english

File:

PDF, 758 KB

english, 2004

16

Principal pathway coupling agonist binding to channel gating in nicotinic receptors

Lee, Won Yong, Sine, Steven M.

Journal:

Year:

2005

Language:

english

File:

PDF, 3.42 MB

english, 2005

17

Recent advances in Cys-loop receptor structure and function

Sine, Steven M., Engel, Andrew G.

Journal:

Year:

2006

Language:

english

File:

PDF, 821 KB

english, 2006

18

Detection and trapping of intermediate states priming nicotinic receptor channel opening

Mukhtasimova, Nuriya, Lee, Won Yong, Wang, Hai-Long, Sine, Steven M.

Journal:

Year:

2009

Language:

english

File:

PDF, 825 KB

english, 2009

19

Neurological diseases: Sleuthing molecular targets for neurological diseases at the neuromuscular junction

Engel, Andrew G., Ohno, Kinji, Sine, Steven M.

Journal:

Nature Reviews Neuroscience

Year:

2003

Language:

english

File:

PDF, 3.91 MB

english, 2003

20

Mechanistic Diversity Underlying Fast Channel Congenital Myasthenic Syndromes

STEVEN M. SINE, HAI-LONG WANG, KINJI OHNO, XIN-MING SHEN, WON YONG LEE, ANDREW G. ENGEL

Journal:

Annals of the New York Academy of Sciences

Year:

2003

File:

PDF, 1.75 MB

2003

21

Congenital Myasthenic Syndromes: Multiple Molecular Targets at the Neuromuscular Junction

ANDREW G. ENGEL, KINJI OHNO, XIN-MING SHEN, STEVEN M. SINE

Journal:

Annals of the New York Academy of Sciences

Year:

2003

File:

PDF, 4.70 MB

2003

22

Recent Structural and Mechanistic Insights into Endplate Acetylcholine Receptors

Steven M. Sine, Fan Gao, Won Yong Lee, Nuriya Mukhtasimova, Hai-Long Wang, Andrew G. Engel

Journal:

Annals of the New York Academy of Sciences

Year:

2008

Language:

english

File:

PDF, 397 KB

english, 2008

23

Further Observations in Congenital Myasthenic Syndromes

Andrew G. Engel, Xin-Ming Shen, Duygu Selcen, Steven M. Sine

Journal:

Annals of the New York Academy of Sciences

Year:

2008

Language:

english

File:

PDF, 549 KB

english, 2008

24

Congenital myasthenic syndromes: A diverse array of molecular targets

Andrew G. Engel, Kinji Ohno, Steven M. Sine

Journal:

Brain Cell Biology

Year:

2003

Language:

english

File:

PDF, 1.02 MB

english, 2003

25

The spectrum of congenital myasthenic syndromes

Andrew G. Engel, Kinji Ohno, Steven M. Sine

Journal:

Molecular Neurobiology

Year:

2002

Language:

english

File:

PDF, 286 KB

english, 2002

26

Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist

Li, Shu-Xing, Huang, Sun, Bren, Nina, Noridomi, Kaori, Dellisanti, Cosma D, Sine, Steven M, Chen, Lin

Journal:

Nature Neuroscience

Year:

2011

Language:

english

File:

PDF, 2.03 MB

english, 2011

27

Investigation of biological reactor designs for treatment of methanol and thiodiglycol waste streams

Brian J. Sines, Eric W. Teather, Steven P. Harvey, William A. Weigand

Journal:

Applied Biochemistry and Biotechnology

Year:

1994

Language:

english

File:

PDF, 750 KB

english, 1994

28

Toxins selective for subunit interfaces as probes of nicotinic acetylcholine receptor structure

Palmer Taylor, Hitoshi Osaka, Brian E. Molles, Naoya Sugiyama, Pascale Marchot, Elizabeth J. Ackermann, Siobhan Malany, Joseph J. McArdle, Steven M. Sine, Igor Tsigelny

Journal:

Journal of Physiology-Paris

Year:

1998

Language:

english

File:

PDF, 430 KB

english, 1998

29

Molecular dissection of subunit interfaces in the nicotinic acetylcholine receptor

Steven M. Sine, Nina Bren, Polly A. Quiram

Journal:

Journal of Physiology-Paris

Year:

1998

Language:

english

File:

PDF, 419 KB

english, 1998

30

Congenital myasthenic syndromes: Experiments of nature

Andrew G. Engel, Kinji Ohno, Steven M. Sine

Journal:

Journal of Physiology-Paris

Year:

1998

Language:

english

File:

PDF, 398 KB

english, 1998

31

Molecular dissection of subunit interfaces in the acetylcholine receptor: Identification of determinants of α-Conotoxin M1 selectivity

Steven M. Sines, Hans-Jurgen Kreienkamp, Nina Bren, Robert Maeda, Palmer Taylor

Journal:

Year:

1995

Language:

english

File:

PDF, 1.06 MB

english, 1995

32

Current understanding of congenital myasthenic syndromes

Andrew G Engel, Steven M Sine

Journal:

Current Opinion in Pharmacology

Year:

2005

Language:

english

File:

PDF, 802 KB

english, 2005

33

Congenital Myasthenic Syndrome Caused by Decreased Agonist Binding Affinity Due to a Mutation in the Acetylcholine Receptor ε Subunit

Kinji Ohno, Hai-Long Wang, Margherita Milone, Nina Bren, Joan M Brengman, Satoshi Nakano, Polly Quiram, Jerry N Pruitt, Steven M Sine, Andrew G Engel

Journal:

Year:

1996

Language:

english

File:

PDF, 1.16 MB

english, 1996

34

Mode Switching Kinetics Produced by a Naturally Occurring Mutation in the Cytoplasmic Loop of the Human Acetylcholine Receptor ε Subunit

Margherita Milone, Hai-Long Wang, Kinji Ohno, Richard Prince, Takayasu Fukudome, Xin-Ming Shen, Joan M. Brengman, Robert C. Griggs, Steven M. Sine, Andrew G. Engel

Journal:

Year:

1998

Language:

english

File:

PDF, 898 KB

english, 1998

35

Structural basis of the different gating kinetics of fetal and adult acetylcholine receptors

Cecilia Bouzat, Nina Bren, Steven M. Sine

Journal:

Year:

1994

Language:

english

File:

PDF, 1.00 MB

english, 1994

36

Subunit-Selective Contribution to Channel Gating of the M4 Domain of the Nicotinic Receptor

Bouzat, Cecilia, Gumilar, Fernanda, del Carmen Esandi, María, Sine, Steven M.

Journal:

Biophysical Journal

Year:

2002

Language:

english

File:

PDF, 259 KB

english, 2002

37

Asymmetric Structural Motions of the Homomeric α7 Nicotinic Receptor Ligand Binding Domain Revealed by Molecular Dynamics Simulation

Henchman, Richard H., Wang, Hai-Long, Sine, Steven M., Taylor, Palmer, McCammon, J. Andrew

Journal:

Biophysical Journal

Year:

2003

Language:

english

File:

PDF, 528 KB

english, 2003

38

Novel Modulation of Neuronal Nicotinic Acetylcholine Receptors by Association with the Endogenous Prototoxin lynx1

Inés Ibañez-Tallon, Julie M Miwa, Hai-Long Wang, Niels C Adams, Gregg W Crabtree, Steven M Sine, Nathaniel Heintz

Journal:

Year:

2002

Language:

english

File:

PDF, 428 KB

english, 2002

39

Ligand occupation and the functional states of the nicotinic-cholinergic receptor

Palmer Taylor, Steven M. Sine

Journal:

Trends in Pharmacological Sciences

Year:

1982

Language:

english

File:

PDF, 534 KB

english, 1982

40

Single Channel Current Through Nicotinic Receptor Produced By Closure Of The Binding Site C-loop

Wang, Hai-Long, Sine, Steven M.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 76 KB

english, 2009

41

Electrical Fingerprinting Reveals Agonist Binding Sites Required for Activation of Homo-pentameric Cys-loop Receptors

Bouzat, Cecilia B., Rayes, Diego, De Rosa, Maria Jose, Sine, Steven M.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 76 KB

english, 2009

42

Detection and Trapping of Elusive Priming Intermediates Towards Open Nicotinic Receptor Channel

Mukhtasimoova, Nuriya F., Lee, Won Yong, Wang, Hai-Long, Sine, Steven M.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 76 KB

english, 2009

43

Single-Channel Current Through Nicotinic Receptor Produced by Closure of Binding Site C-Loop

Wang, Hai-Long, Toghraee, Reza, Papke, David, Cheng, Xiao-Lin, McCammon, J. Andrew, Ravaioli, Umberto, Sine, Steven M.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 1.48 MB

english, 2009

44

Molecular-Dynamics Simulations of ELIC—a Prokaryotic Homologue of the Nicotinic Acetylcholine Receptor

Cheng, Xiaolin, Ivanov, Ivaylo, Wang, Hailong, Sine, Steven M., McCammon, J. Andrew

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 1.45 MB

english, 2009

45

Molecular Dynamics Simulation Reveals a Possible Mechanism of Activation of the Prokaryotic Proton Activated Channel Glic

Wang, Hai-Long, Sine, Steven M.

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 37 KB

english, 2010

46

Epibatidine Activates Muscle Acetylcholine Receptors with Unique Site Selectivity

Prince, Richard J., Sine, Steven M.

Journal:

Biophysical Journal

Year:

1998

Language:

english

File:

PDF, 228 KB

english, 1998

47

New horizons for congenital myasthenic syndromes

Engel, Andrew G., Shen, Xin-Ming, Selcen, Duygu, Sine, Steven

Journal:

Annals of the New York Academy of Sciences

Year:

2012

Language:

english

File:

PDF, 1.03 MB

english, 2012

48

Ligand-Induced Conformational Change in the α7 Nicotinic Receptor Ligand Binding Domain

Henchman, Richard H., Wang, Hai-Long, Sine, Steven M., Taylor, Palmer, Andrew McCammon, J.

Journal:

Biophysical Journal

Year:

2005

Language:

english

File:

PDF, 1.10 MB

english, 2005

49

Nanosecond-Timescale Conformational Dynamics of the Human α7 Nicotinic Acetylcholine Receptor

Cheng, Xiaolin, Ivanov, Ivaylo, Wang, Hailong, Sine, Steven M., McCammon, J. Andrew

Journal:

Biophysical Journal

Year:

2007

Language:

english

File:

PDF, 1.30 MB

english, 2007

50

Number of Extracellular-Transmembrane Interfaces Required for Activation of Homomeric Cys-Loop Receptors

Andersen, Natalia, Corradi, Jeremias, Bartos, Mariana, Sine, Steven M., Bouzat, Cecilia B.

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 38 KB

english, 2011

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